Experimental drug Lecanemab slows down the cognitive deterioration in people with early onset Alzheimer’s.
The trial has been under work for quite a while and is a breakthrough in dementia research. Especially after the spark of high risks among people and its concerns.
Lecanemab is a monoclonal antibody. It actively removes amyloid-beta, which builds up in the brains of people with Alzheimer’s. The researchers conducted an 18-month trial among 1800 people, which revealed the drug slowed the functional and cognitive impairment by 27% in early Alzheimer’s participants.
The makers of the drug Biogen and Eisai were very excited about this trial, now published in The New England Journal of Medicine.
Research Director, Alzheimer’s Research UK, Dr. Susan Kohlhaas said,
She further added,
Is the drug safe?
Although promising results are seen after the trial, there is a concern about the number of deaths. Moreover, whether the drug is safe to take, especially in people taking blood thinners.
Two people died after taking the drug during the trial based on the media reports. One of them was a 65-year-old woman who died because of a massive haemorrhage in the brain. Researchers link her demise to the drug. Whereas the other death was of an 80-year-old who was on blood thinners for his heart disease.
Moreover, other than these two deaths, the trail data shows that six patients treated with lecanemab suffered strokes.
However, Bigon and Eisai denied any of the risks linked with the trial. According to them, the deaths had no link with the treatment. Moreover, the number of deaths in the placebo group and lecanemab group was the same.
Professor of Old Age Psychiatry, Rob Howard commented on the research