SARS-CoV-2 Infection

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Severe acute respiratory syndrome SARS-CoV-2 is an important cause of lower respiratory tract infection. This case study uses in vitro models of the lungs to elucidate the consequences and cellular targets of the viral infection.

Severe acute respiratory syndrome was inoculated into human bronchial epithelial cells in laboratory settings, in a biosafety level 3 facility. Similarly, the facility had a multiplicity of infection which indicated the ratio of 3:1 virus particles targeting the airway cells. The cells were examined 96 hours after the infection presented using scanning electron microscopy.

Panel A shows an infected ciliated cell with strands of mucus attached to the tips of the cilia. Panel B shows an image at higher magnification with the structure and density of SARS-CoV-2 virions produced by human airway epithelial cells. The production of virus was approximately 3×106 plaque-forming units per culture. The findings showed that a higher number of virions are produced and released per cell.

References

Ehre, C. (2020). SARS-CoV-2 Infection of Airway Cells. New England Journal of Medicine383(10), 969-969.

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Dr. Aiman Shahab is a dentist with a bachelor’s degree from Dow University of Health Sciences. She is an experienced freelance writer with a demonstrated history of working in the health industry. Skilled in general dentistry, she is currently working as an associate dentist at a private dental clinic in Karachi, freelance content writer and as a part time science instructor with Little Medical School. She has also been an ambassador for PDC in the past from the year 2016 – 2018, and her responsibilities included acting as a representative and volunteer for PDC with an intention to make the dental community of Pakistan more connected and to work for benefiting the underprivileged. When she’s not working, you’ll either find her reading or aimlessly walking around for the sake of exploring. Her future plans include getting a master’s degree in maxillofacial and oral surgery, settled in a metropolitan city of North America.

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