Peptide-based hydrogel for tissue and organ repair

Peptide based hydrogel

A team of scientists led by uOttawa has invented a peptide-based hydrogel that combines biomedical sophistication with nature-inspired engineering. This material shows enormous potential for on-the-spot restoration of a stunning spectrum of injured human body tissues and organs.

An innovative study co-led by Dr. Emilio I. Alarcón, associate professor of medicine at the University of Ottawa, has the potential to save millions of lives in the future by developing peptide-based hydrogels that can repair damaged corneas, heal wounds on the skin, and carry medications to the damaged heart muscle.

Hydrogels are a water-based material with a gelatinous texture that has shown promise in therapeutic applications. These peptides are chemicals found in living things.

The study, published in Advanced Functional Materials and co-led by Drs. Erik Suuronen and Marc Ruel, use a novel method. The biomaterial developed by the joint team is enhanced by designed peptides, in contrast to the majority of hydrogels investigated in tissue engineering, which are obtained from animals and proteins. It easily translates more clinically as a result.

 Dr. Ruel says

The publication by Dr. Alarcón in Advanced Functional Materials reveals a novel way to make wound healing, organ healing, and even basic scarring after surgery much more therapeutically modulatable, and therefore, optimizable for human health.”

The modulation of peptide-based biomaterial is indeed crucial. The Ottawa-led research developed a robust material for a previously unanticipated range of tissues due to the hydrogels’ adaptable architecture. Essentially, the two-component system is easier to adjust to boost adhesiveness or reduce other components based on which part of the body is undergoing repair.


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