Cortisol Levels Measured With Earwax

Earwax Samples Help Measure Cortisol Levels
Source: Shutterstock

Researchers at University College London have designed a new sampling method that allows measurement of the stress hormone, cortisol, from your earwax

It seems like that sticky stuff inside your ear might be more useful than we thought. In a study published in the journal Heliyon, researchers have found the bacteriostatic properties of the earwax make it a likely candidate for measuring cortisol levels.

Cortisol, the stress hormone, reveals more than just your stress level. It can help regulate blood sugar levels, control blood pressure, and aid metabolism. Furthermore, cortisol levels are also a biomarker for depression.

However, obtaining accurate measurements of cortisol is a real challenge.

Cortisol sampling is notoriously difficult, as levels of the hormone can fluctuate, so a sample might not be an accurate reflection of a person’s chronic cortisol levels. Moreover, sampling methods themselves can induce stress and influence the results

Dr. Andres Herane-Vives, lead researcher

Earwax Sampling Device for Cortisol Levels

Similar to a q-tip, the device takes a swab of the earwax from inside the ear. However, to prevent the swab from going too far inside, researchers have designed a brake within the device. The tip is covered by a sponge containing a solution. This allows for a reliable and effective method of taking samples. Thus, allowing for a quick, cheap, and effective at-home method of taking a sample.

The self-sampling device designed to measure cortisol levels.
The self-sampling device designed to measure cortisol levels.
Credit: UCL

The current method of cortisol sampling includes blood and hair specimens. Generally, hair specimens help measure chronic cortisol levels. However, local stressors can affect the concentration of the hormone. Thus, causing researchers to argue that it might not be the most appropriate or accurate method.

Earwax Yields More Cortisol Than Hair

A slightly painful syringe procedure helped collect earwax samples. A month later, participants underwent the same procedure in one ear and the newly developed sampling technique in the other ear. They administered the new sampling technique by themselves. 

Cortisol concentrations in the earwax, hair, and serum samples of all 37 participants was compared with each other.

The findings showed the cortisol concentration from the earwax samples was higher than in hair, although serum samples contained more cortisol than both.

Furthermore, along with yielding more concentration of the hormone the device was also rated as the most comfortable method out of all. Additionally, it was least affected by confounding factors such as stressful events. 

After this successful pilot study, if our device holds up to further scrutiny in larger trials, we hope to transform diagnostics and care for millions of people with depression or cortisol-related conditions such as Addison’s disease and Cushing syndrome, and potentially numerous other conditions.

Dr. Andres Herane-Vives, lead researcher

Reference:

Herane-Vives, Andres, et al. “Measuring Earwax Cortisol Concentration Using a Non-Stressful Sampling Method.” Heliyon, vol. 6, no. 11, 2020, doi:10.1016/j.heliyon.2020.e05124. 

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