CAR T Modification Can Fight Fungal Lung Infections


Researchers have created cells using CAR T that can assist fight fungal infections in the lungs

A team of researchers has come through with a way that can modify CAR T engineering process for creating cells, which can fight against fungal infections in the lung. The paper was published in the journal Science Translational Medicine where the group described modifying the engineering process.

(Chimeric Antigen Receptor) CAR T Cells

Chimeric Antigen Receptor T cells are engineered genetically for attaching to the cancer cell antigens, which help in the elimination of tumours. These cells are engineered through harvesting T cells in a patient and by adding a gene receptor later. After the former two processes, these CAR T cells are injected back.

These cells are specifically engineered for fighting cancer, but this modification effort will help cater to Aspergillus fumigatus. A. fumigatus causes infections in patients who are immunocompromised and those undergoing chemotherapy, which results in invasive pulmonary aspergillosis. Furthermore, researchers have also found that those who have the COVID-19 infection have increased susceptibility to lung infections.

The modification process is a close mimic of the procedure used for creating cancer-fighting CAR T cells. However, instead of a gene receptor targeting cancer cell antigens, a receptor that targets the cell wall of A. fumigatus is added.

The first test was done using a petri dish where they were able to recognize multiple strains of A. fumigatus. Moreover, they also observed that CAR T cells impeded fungal growth by letting proteins and granzyme B escape from individual fungi, by such means, killing them.

Furthermore, the researchers also tested their cells on lab mice. It revealed that CAR T cells moved to the infection site directly, attaching to the fungi. The fungal level was also lowered, which helped the immune system remove the infection.

Final Verdict

The researchers also suggest that T cells engineered like those to treat cancer cells can be utilized for other applications. For example, fighting fungal infections.

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Dr. Armash Shahab is a dentist with a bachelor's degree from Dow University of Health Sciences. She is skilled in general dentistry and is an experienced medical content writer. Her future plans are to work for the betterment of dentistry for the underprivileged in Pakistan, apply for postgraduation, and specialize in Paediatric Dentistry.


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