Suicide With Caffeine Overdose!

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caffeine overdose

A healthy teenager attempts suicide by overdosing on pills containing caffeine- A case of caffeine overdose!

An otherwise healthy, 18-year-old, Japanese male attempted suicide by ingesting 60 caffeinated tablets. The total caffeine content was approximately 6.0 g.  He was brought to the emergency department 80 minutes later when he developed nausea and headache as a result of caffeine overdose.

Past history of the patient revealed maladjustment to high school after he hit his friend due to which his school principal suspended him for 10 days. Besides this, he had no remarkable personal or family history. The patient was a non-smoker with no significant medical or psychiatric history. However, examination revealed a scar on his wrist demonstrating a healed cut.

In the emergency department, his Glasgow Coma Scale score was 15, blood pressure was 152/82 mmHg, pulse was 139 beats/min, respiratory rate was 22/min, saturation of oxygen was 100% on room air, and body temperature was 36.8 °C.

Physical examination revealed a young male of normal height and built. His lungs were clear on auscultation with normal breath sounds. Cardiac auscultation revealed a regular but rapid heart rhythm with systolic ejection murmur.

The doctors in the ER performed an electrocardiogram (ECG) which showed sinus tachycardia at a rate of 139 beats/min with QT prolongation (QTc 617 ms).

Serological investigation showed:
  • Lactic acidosis on arterial blood gas (ABGs) results (lactate 3.8 mmol/L)
  • White blood cells: 11,120/mcL
  • Hemoglobin: 17.4 g/dL
  • Platelets: 24.5×104/mcL
  • Blood urea nitrogen: 13 mg/dL (4.6 mmol/L)
  • Serum creatinine: 0.73 mg/dL (64.5 mcmol/L)
  • Sodium: 142 mmol/L
  • Potassium: 2.6 mmol/L
  • Chloride: 103 mmol/L
  • Creatinine phosphokinase: 126 IU/L

Systemic computed tomography (CT) scan was unremarkable.

In the ER, the doctors performed gastric lavage of 1600 mL and administered 30 g of activated charcoal through a nasogastric (NG) tube. Additionally, they administered 20 mmol of potassium at the rate of 20 mmol/hour. Subsequently, they shifted the patient to the intensive care unit.

To score the agitation, the patient scored + 2 on the Richmond Agitation-Sedation Scale. The doctors suspected and made a working diagnosis of acute caffeine poisoning. The patient received dexmedetomidine (maximum 0.7 µg/kg/hour).

After 7 hours, his serum potassium and lactate levels normalized to 3.7 mmol/L and 1 mmol/L, respectively. Moreover, his ECG also improved, i.e. the QTc normalized.

After 12 hours, the doctors stopped the administration of dexmedetomidine. However, the patient had persistent suicidal thoughts and ideation, therefore, he required psychiatric ward admission for protection. He admitted having thoughts of dying since high school.

However, by the third day of admission, he had improved and no longer had suicide ideation, therefore he was discharged home.

Is caffeine overdose lethal?

Normally, with caffeine doses of 0.05 g to 0.2 g, individuals may experience some mild stimulation, however,  acutely ingested doses of more than 5 grams can be lethal. However, the reported cases with fatal caffeine intoxication are rare. Moreover, the absorption and half-life of caffeine within the body varies from person to person and is dependent on multiple factors including gender, age, oral contraceptives’ use, pregnancy, and smoking. Therefore, lethal caffeine doses may greatly vary from one person to another.

Reference:

Kitano, T., Okajima, M., Sato, K. et al. Suicidal attempt with caffeine overdose treated with dexmedetomidine: a case report. J Med Case Reports 15, 11 (2021). https://doi.org/10.1186/s13256-020-02611-6

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Dr. Arsia Hanif has been a meritorious Healthcare professional with a proven track record throughout her academic life securing first position in her MCAT examination and then, in 2017, she successfully completed her Bachelors of Medicine and Surgery from Dow University of Health Sciences. She has had the opportunity to apply her theoretical knowledge to the real-life scenarios, as a House Officer (HO) serving at Civil Hospital. Whilst working at the Civil Hospital, she discovered that nothing satisfies her more than helping other humans in need and since then has made a commitment to implement her expertise in the field of medicine to cure the sick and regain the state of health and well-being. Being a Doctor is exactly what you’d think it’s like. She is the colleague at work that everyone wants to know but nobody wants to be. If you want to get something done, you approach her – everyone knows that! She is currently studying with Medical Council of Canada and aspires to be a leading Neurologist someday. Alongside, she has taken up medical writing to exercise her skills of delivering comprehensible version of the otherwise difficult medical literature. Her breaks comprise either of swimming, volunteering services at a Medical Camp or spending time with family.

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