A 62-year old man presented to the clinic with complaints of distention, diarrhoea and weight loss. He stated that the gastrointestinal problems started 5 months ago and the patient lost around 8 kg weight during this time. شرح لعبة روليت
Past history
He had a medical history of localised oral clear-cell sarcoma that was diagnosed 2 years ago. He got the sarcoma excised without any further treatment. Physical examination of the patient showed abdominal distension and an enlarged lymph node. العاب فلوس حقيقية In addition, CT scan of the abdomen was performed which showed numerous grape-like nodules.
Histopathological analysis of a biopsied abdominal lesion was consistent with clear cell sarcoma. لعبة تربح منها فلوس The immunohistochemical analysis showed reactivity to monoclonal antibody HMB45 and was positive for S100 protein.
Clear cell sarcoma
Clear cell sarcoma is a malignant tumour of the soft tissue. The tumour is a derivative of the neural crest cells and shared ultrastructure, immunohistochemical and morphologic similariites with malignant melanoma. However, it is uncommon for the cancer to affect the oral and abdominal cavities, it typically affects the limbs of young adults.
Treatment of clear cell sarcoma typically involves surgical resection and the effects of adjuvant therapy are uncertain. In this case, the patient declined further treatment after four cycles of targeted therapy and was shifted to hospice care. He died 9 months after presenting with illness.
References
Huang, X., & Liao, X. (2020). Metastatic Clear-Cell Sarcoma. New England Journal of Medicine, 383(4), 379-379.
